Thermo Fisher Scientific
Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science, with annual revenue of approximately $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, increasing productivity in their laboratories, improving patient health through diagnostics or the development and manufacture of life-changing therapies, we are here to support them.
High Purity New England
High Purity New England is a manufacturer and distributor of bioprocessing solutions, including chromatography columns, custom single-use assemblies, bioreactors, sensors, pumps, and much more. They are committed to advancing their customer’s bioprocessing objectives from discovery to commercial launch with their comprehensive selection of products and services that are backed by a deep understanding of biopharmaceutical unit operations.
TriLink BioTechnologies, part of Maravai LifeSciences, is a CDMO helping life science leaders and innovators overcome challenges in the synthesis and scale-up of nucleic acids, NTPs and mRNA capping analogs with scale-up expertise and unique mRNA production capabilities, including its proprietary CleanCap® mRNA capping technology. TriLink continues to expand its cGMP and general mRNA, oligonucleotide & plasmid manufacturing capacity at its new global headquarters in San Diego California, to support therapeutic, vaccine and diagnostic customers.
Levitronix® is the worldwide leader in magnetically levitated bearingless motor technology, specializing in supplying process equipment for Biotech, Microelectronics and Industrial Applications. Levitronix’ products range from pump systems, mixers, and blowers to flow sensors and viscometers.
Novel, targeted ways to treat diseases like gene therapy, DNA and mRNA vaccines, exosomes, and stem cells imply new manufacturing challenges. Dealing with very shear sensitive particles like cells, LNPs or viral vectors, especially in a continuous, sterile, or single-use processes, relate to new process equipment requirements. Levitronix® process equipment is intended to handle demanding fluid applications ensuring the highest product yields.
Levitronix® PuraLev® pumps are ultra-low shear and pulsation-free by design, minimizing particle degradation or aggregation. Levitronix® PuraLev® mixers enable effective low-shear mixing over a wide operating range. And for optimal flow control, Levitronix® LEVIFLOW® flow sensors ensure high-precision flow measurement.
Curia is an end-to-end Contract Research, Development and Manufacturing Organization (CRDMO) with expertise in biologics and small molecule drugs gained over decades serving pharmaceutical and biotechnology companies. Our teams offer a comprehensive suite of services from discovery to manufacturing of mRNA therapeutics, including vector engineering, linearized plasmid production suitable for manufacturing, process development, drug substance manufacturing, lipid synthesis, LNP-mRNA formulation, drug product fill/finish, analytics and quality control assays.
We have experience with both non-replicating and self-amplifying mRNAs and have synthesized molecules larger than 16 kb at scales ranging from milligram to multigram quantities. Single-use technologies and animal component-free raw materials are important elements of our manufacturing processes. Our comprehensive suite of on-site analytics and quality control assays streamline process development and batch release.
Centre for Process Innovation
At CPI, we help companies to develop, optimise and scale-up novel RNA therapies and vaccines.
As a result of our role in the UK Government’s vaccine task force, we are the only UK-based company currently capable of developing, manufacturing and encapsulating messenger and self-amplifying RNA vaccines and therapies ready for use in clinical trials in one location, through our end-to-end process for RNA development and scale-up. From our new RNA Centre of Excellence in the North East of England, companies can benefit from our process agnostic platform in a GMP environment.
Pfanstiehl Inc. is a cGMP Manufacturer of High Purity Low Endotoxin components such as Trehalose, Sucrose, Mannitol, Maltose, Galactose (non-animal), Mannose and Amino Acids such as L-Arginine and Histidine for Biologics, Biosimilars, Vaccines, Cell Culture Media and Injectables (liquid & lyo) located in Waukegan Illinois USA. Pfanstiehl has been in operation since 1919, focusing on both Biopharmaceutical excipients / critical components & Pharmaceutical HPAPIs / APIs (generic and on contract manufacturing base). Pfanstiehl specializes in isolation, purification, custom synthesis and scale-up development of regulated, high purity and low endotoxin Injectable Formulation Ingredients, Pharmaceutical Intermediates and Active Pharmaceutical Ingredients, in gram to multi-ton commercial quantities.
Since its foundation in 1977, Lipoid has gained an outstanding reputation in the development and industrial production of high-quality lecithin, phospholipids, and other lipid products, meeting the high standards of the pharmaceutical industry. Lipoid is the world’s leading company for the production and supply of a wide range of natural and synthetic phospholipid excipients on an industrial scale.
New England Biolabs
Established in the mid 1970's, New England Biolabs, Inc. (NEB) is the industry leader in the discovery and production of enzymes for molecular biology applications and now offers the largest selection of recombinant and native enzymes for genomic research. NEB continues to expand its product offerings into areas related to PCR, gene expression, sample preparation for next generation sequencing, synthetic biology, glycobiology, epigenetics and RNA analysis. Additionally, NEB is focused on enabling new technologies in key market sectors, including molecular diagnostics, clinical sequencing, and nucleic acid-based therapeutics and vaccines.